Mankhwala ophera tizilombo kwa nthawi yayitali amalonjeza kuthandiza kulimbana ndi miliri

A UCF alum ndi ofufuza angapo adagwiritsa ntchito nanotechnology kupanga choyeretsa ichi, chomwe chimatha kukana ma virus asanu ndi awiri mpaka masiku 7.
Ofufuza a UCF apanga mankhwala ophera tizilombo toyambitsa matenda opangidwa ndi nanoparticle omwe amatha kupha ma virus padziko lapansi mpaka masiku 7 - zomwe apezazi zitha kukhala chida champhamvu polimbana ndi COVID-19 ndi ma virus ena omwe akubwera.
Kafukufukuyu adasindikizidwa sabata ino mu nyuzipepala ya ACS Nano ya American Chemical Society ndi gulu lamitundu yambiri la akatswiri a virus ndi engineering ochokera ku yunivesite komanso wamkulu wa kampani yaukadaulo ku Orlando.
Christina Drake '07PhD, woyambitsa Kismet Technologies, adadzozedwa ndi ulendo wopita ku golosale koyambirira kwa mliriwu ndipo adapanga mankhwala ophera tizilombo. Kumeneko, anaona wantchito akupopera mankhwala ophera tizilombo pa chogwirira cha firiji ndipo nthawi yomweyo anapukutapo mankhwalawo.
"Poyamba lingaliro langa linali lopanga mankhwala opha tizilombo mwachangu," adatero, "koma tidalankhula ndi ogula monga madotolo ndi madokotala kuti amvetsetse mankhwala omwe akufuna. Chofunikira kwambiri kwa iwo ndi chinthu chokhalitsa, chipitiliza kupha malo olumikizana kwambiri monga zogwirira zitseko ndi pansi kwanthawi yayitali mukatha kugwiritsa ntchito. ”
Drake amagwira ntchito ndi Sudipta Seal, injiniya wa UCF komanso katswiri wa sayansi ya nanoscience, ndi Griff Parks, katswiri wa ma virus, wothandizana nawo kafukufuku wa Sukulu ya Zamankhwala, komanso dean wa Burnett School of Biomedical Science. Ndi ndalama zochokera ku National Science Foundation, Kismet Tech, ndi Florida High-Tech Corridor, ofufuza apanga mankhwala opha tizilombo toyambitsa matenda opangidwa ndi nanoparticle.
Zomwe zimagwiritsidwa ntchito ndi nanostructure yotchedwa cerium oxide, yomwe imadziwika ndi mphamvu zake zotsitsimutsa antioxidant. Cerium oxide nanoparticles amasinthidwa ndi siliva pang'ono kuti apange mphamvu yolimbana ndi tizilombo toyambitsa matenda.
"Zimagwira ntchito mu chemistry ndi makina," adatero Seal, yemwe wakhala akuphunzira nanotechnology kwa zaka zoposa 20. "Nanoparticles amatulutsa ma electron kuti awononge kachilomboka ndikupangitsa kuti zisagwire ntchito. Mwamwayi, amadziphatikizanso ndi kachilomboka ndikung'ambika pamwamba, ngati kuphulika kwa baluni. ”
Nthawi zambiri zopukuta kapena zopopera zitha kupha tizilombo pamwamba patatha mphindi zitatu kapena zisanu ndi chimodzi mutagwiritsa ntchito, koma palibe chotsalira. Izi zikutanthauza kuti pamwamba pafunika kupukuta mobwerezabwereza kuti ikhale yaukhondo kupewa kutenga ma virus angapo monga COVID-19. Mapangidwe a nanoparticle amakhalabe okhoza kuyambitsa tizilombo toyambitsa matenda ndipo akupitiriza kupha tizilombo toyambitsa matenda padziko lapansi kwa masiku 7 mutatha kugwiritsa ntchito kamodzi.
"Zopha tizilombo toyambitsa matenda zikuwonetsa ntchito yayikulu yolimbana ndi ma virus asanu ndi awiri osiyanasiyana," adatero Parks, yemwe labotale yake imayang'anira kukana kwa "dikishonale" ya kachilomboka. "Sizimangowonetsa ma antivayirasi olimbana ndi ma coronaviruses ndi ma rhinoviruses, komanso zimatsimikizira kuti ndizothandiza polimbana ndi ma virus ena osiyanasiyana omwe ali ndi mawonekedwe osiyanasiyana komanso zovuta. Tikukhulupirira kuti ndi luso lodabwitsali lopha, mankhwala ophera tizilombowa adzakhalanso chida chothandiza polimbana ndi ma virus ena omwe angotuluka kumene. ”
Asayansi akukhulupirira kuti yankholi likhudza kwambiri chilengedwe, makamaka kuchepetsa kuchuluka kwa matenda obwera kuchipatala, monga methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa ndi Clostridium difficile—— Amakhudza oposa mmodzi mwa 30 odwala adaloledwa kuzipatala zaku America.
Mosiyana ndi mankhwala ambiri ophera tizilombo, njira imeneyi ilibe mankhwala owopsa, zomwe zimasonyeza kuti ndi zotetezeka kugwiritsa ntchito pamtunda uliwonse. Malinga ndi zomwe bungwe la US Environmental Protection Agency likufuna, kuyezetsa koyang'anira khungu ndi kuyabwa kwamaso sikuwonetsa zotsatira zoyipa.
"Njira zambiri zophera tizilombo m'nyumba zomwe zilipo pakadali pano zili ndi mankhwala omwe ndi owopsa m'thupi atawonekera mobwerezabwereza," adatero Drake. "Zogulitsa zathu zopangidwa ndi nanoparticle zidzakhala ndi chitetezo chokwanira, chomwe chidzathandiza kwambiri kuchepetsa kukhudzidwa kwa anthu ndi mankhwala."
Kafukufuku wochulukirapo akufunika zinthu zisanalowe mumsika, ndichifukwa chake gawo lotsatira la kafukufuku lidzayang'ana kwambiri momwe mankhwala ophera tizilombo amagwirira ntchito kunja kwa labotale. Ntchitoyi iphunzira momwe mankhwala ophera tizilombo amakhudzidwa ndi zinthu zakunja monga kutentha kapena kuwala kwa dzuwa. Gululi likukambirana ndi netiweki yachipatala yakumaloko kuti ayesere mankhwalawa m'malo awo.
"Tikuyang'ananso chitukuko cha filimu yokhazikika kuti tiwone ngati tingathe kuphimba ndi kusindikiza zipatala zapansi kapena zitseko za zitseko, malo omwe amafunika kupha tizilombo toyambitsa matenda, kapena malo omwe amalumikizana nawo mosalekeza," adatero Drake.
Seal adalumikizana ndi UCF's department of Materials Science and Engineering mu 1997, yomwe ndi gawo la UCF School of Engineering ndi Computer Science. Prosthesis. Iye ndi mkulu wakale wa UCF Nano Science and Technology Center ndi Advanced Materials Processing and Analysis Center. Analandira PhD mu engineering engineering kuchokera ku yunivesite ya Wisconsin, ali ndi mwana wamng'ono mu biochemistry, ndipo ndi wofufuza pambuyo pa udokotala ku Lawrence Berkeley National Laboratory ku yunivesite ya California, Berkeley.
Atagwira ntchito ku Wake Forest School of Medicine kwa zaka 20, Parkes adabwera ku UCF ku 2014, komwe adakhala pulofesa komanso wamkulu wa dipatimenti ya Microbiology ndi Immunology. Iye analandira Ph.D. mu biochemistry kuchokera ku yunivesite ya Wisconsin ndipo ndi wofufuza wa American Cancer Society ku Northwestern University.
Phunziroli linalembedwa ndi Candace Fox, wofufuza za postdoctoral ku School of Medicine, ndi Craig Neal wochokera ku School of Engineering ndi Computer Science. Tamil Sakthivel, Udit Kumar, ndi Yifei Fu, ophunzira omaliza maphunziro a School of Engineering ndi Computer Science, nawonso ndi olemba anzawo.