Akatswiri a MIT adapanga guluu wamphamvu, wogwirizana ndi biocompatible womwe umatha kusindikiza minofu yovulala ndikusiya kutulutsa magazi, kuwuziridwa ndi chinthu chomata chomwe ma barnacles amagwiritsa ntchito kumamatira kumiyala. Ngongole: zithunzi za stock
Zomatira zatsopano zomwe zimatengera zomata zomwe zimagwiritsidwa ntchito ndi barnacles kumamatira kumiyala zingapereke njira yabwinoko yochizira kuvulala.
Motsogozedwa ndi chinthu chomata chomwe ma barnacles amagwiritsa ntchito kumamatira kumiyala, mainjiniya a MIT adapanga guluu wamphamvu wa biocompatible yemwe amatha kumata minofu yovulala ndikusiya kutuluka magazi.
Ngakhale pamwamba paphimbidwe ndi magazi, phala latsopanoli limatha kumamatira pamwamba ndipo limatha kupanga chidindo cholimba mkati mwa masekondi 15 mutapaka. Akatswiri ofufuza amati guluu umenewu ukhoza kupereka njira yothandiza kwambiri yochizira matenda opweteka komanso kuletsa kutuluka kwa magazi pa nthawi ya opaleshoni.
"Tikuthana ndi vuto lakumatira m'malo ovuta, kutanthauza kuti, malo achinyezi, osinthika a minofu yamunthu. Panthawi imodzimodziyo, tikuyesera kusintha chidziwitso ichi kukhala zinthu zenizeni zomwe zingapulumutse miyoyo, "MIT Machinery Said Zhao Xuanhe, pulofesa wa zomangamanga ndi zomangamanga ndi zachilengedwe komanso m'modzi mwa olemba akuluakulu a phunziroli.
Christoph Nabzdyk ndi dokotala wa opaleshoni yamtima komanso dokotala wamkulu wachipatala ku Mayo Clinic ku Rochester, Minnesota, komanso wolemba wamkulu wa pepalalo, lomwe linasindikizidwa mu Nature Biomedical Engineering pa Ogasiti 9, 2021. Wasayansi wofufuza ku MIT Hyunwoo Yuk ndi mnzake wa postdoctoral Jingjing Wu ndi omwe adalemba kafukufukuyu.
Gulu lofufuza: Hyunwoo Yuk, Jingjing Wu, Xuanhe Zhao (kuchokera kumanzere kupita kumanja), atanyamula chipolopolo cha barnacle ndi barnacle gum hemostatic mafuta m'manja mwawo. Ngongole: Zoperekedwa ndi wofufuza
Kupeza njira yothetsera magazi ndi vuto lomwe lakhalapo kwa nthawi yayitali, koma silinatheretu kwathunthu, adatero Zhao. Ma sutures nthawi zambiri amagwiritsidwa ntchito kutseka mabala, koma ma sutures ndi njira yowononga nthawi yomwe oyankha oyamba nthawi zambiri sangathe kuchita mwadzidzidzi. Pakati pa asilikali, kutaya mwazi ndizomwe zimayambitsa imfa pambuyo pa zoopsa, pamene mwa anthu ambiri, kutaya magazi ndi chifukwa chachiwiri cha imfa pambuyo pa zoopsa.
M'zaka zaposachedwa, zida zina zomwe zimatha kuyimitsa magazi, zomwe zimatchedwanso hemostatic agents, zakhala zikugulitsidwa. Zambiri mwa izi zimakhala ndi zigamba zomwe zimakhala ndi zinthu zomwe zimapangitsa kuti magazi aziundana. Komabe, izi zimatenga mphindi zingapo kupanga chisindikizo ndipo sizigwira ntchito nthawi zonse pamabala otuluka magazi kwambiri.
Laboratory ya Zhao yakhala ikudzipereka kuthetsa vutoli kwa zaka zambiri. Mu 2019, gulu lake lidapanga tepi yambali ziwiri ndikuwonetsa kuti itha kugwiritsidwa ntchito kutseka maopaleshoni. Tepi iyi imalimbikitsidwa ndi zinthu zomata zomwe akangaude amagwiritsa ntchito kuti agwire nyama m'malo achinyezi. Lili ndi ma polysaccharides omwe amatha kuyamwa madzi kuchokera pamwamba nthawi yomweyo, ndikuchotsa tinthu tating'ono touma tomatira.
Chifukwa cha guluu wawo watsopano, ochita kafukufukuwo adakopekanso ndi chilengedwe. Panthawiyi, adaika chidwi chawo pa ma barnacles, omwe ndi ma crustaceans ang'onoang'ono omwe amamangiriridwa ku nyama zina monga miyala, mabwato komanso anamgumi. Malowa amakhala onyowa ndipo nthawi zambiri amakhala auve kwambiri - izi zimapangitsa kuti kumamatira kukhale kovuta.
"Izi zidatikopa chidwi," adatero Yuk. "Izi ndizosangalatsa kwambiri, chifukwa kuti mutseke minofu yotuluka magazi, simuyenera kuthana ndi chinyezi chokha, komanso kuipitsa magazi omwe akutuluka. Tinapeza kuti cholengedwa ichi chokhala m’malo a m’nyanja chikuchita chimodzimodzi chimene tiyenera kuchita kuti tithane nacho. Mavuto otaya magazi ambiri. ”
Kafukufuku wa ofufuza a barnacle chingamu akuwonetsa kuti ili ndi mawonekedwe ake apadera. Mamolekyu a mapuloteni omata omwe amathandiza kuti barnacle ikhale pamwamba amayimitsidwa mumtundu wa mafuta, omwe amatha kuthamangitsa madzi ndi zonyansa zilizonse zomwe zimapezeka pamwamba, kotero kuti puloteni yomatayo ikhale yolimba pamwamba.
Gulu la MIT lidaganiza zoyesa kutsanzira guluuyi posintha zomatira zomwe adapanga kale. Zinthu zowoneka bwinozi zimakhala ndi polima yotchedwa poly(acrylic acid) momwe organic compound yotchedwa NHS ester imayikidwa kuti ipereke zomatira, pomwe chitosan ndi shuga yemwe amalimbitsa zinthuzo. Ochita kafukufuku amaundana ma flakes a zinthuzi, kuwapera kukhala tinthu ting'onoting'ono, kenaka amayimitsa tinthu tating'onoting'ono tamafuta a silikoni achipatala.
Mafutawo akagwiritsidwa ntchito pamalo onyowa (monga minofu yokhala ndi magazi), mafutawo amathamangitsa magazi ndi zinthu zina zomwe zingakhalepo, zomwe zimapangitsa kuti ma viscous particles adutse ndi kupanga chisindikizo cholimba pabalapo. Mayesero a ochita kafukufuku pa mbewa anasonyeza kuti mkati mwa masekondi 15 mpaka 30 atapaka guluuyo, n’kukakamira pang’onopang’ono, guluuyo inalimba ndipo inasiya kutuluka.
Ofufuzawo adanena kuti poyerekeza ndi tepi ya mbali ziwiri yomwe idapangidwa ndi ochita kafukufuku mu 2019, mwayi umodzi wazinthu zatsopanozi ndikuti phala likhoza kupangidwa kuti ligwirizane ndi mabala osasinthasintha, ndipo tepiyo ikhoza kukhala yoyenera kwambiri pa opaleshoni yosindikiza Pangani incision kapena kulumikiza chipangizo chachipatala ku minofu. "Phala lowumba limatha kulowa ndikukwanira mawonekedwe aliwonse osakhazikika komanso osindikizira," adatero Wu. "Izi zimalola ogwiritsa ntchito kuti azitha kuzolowerana ndi mabala otuluka magazi osawoneka bwino."
Poyesa nkhumba, Nabzdyk ndi anzake ku Mayo Clinic adapeza kuti guluuyu akhoza kusiya kutuluka magazi mwamsanga, komanso kuti amagwira ntchito mofulumira komanso mogwira mtima kuposa mankhwala omwe amawayerekeza ndi hemostatic. Zitha kugwiranso ntchito popatsa nkhumba mphamvu yochepetsera magazi (heparin) kuti magazi asapangire kuundana mwangozi.
Kafukufuku wawo akuwonetsa kuti chisindikizocho chimakhalabe bwino kwa milungu ingapo, zomwe zimalola kuti minofuyo ichiritse yokha, ndipo guluu limayambitsa kutupa pang'ono, mofanana ndi kutupa komwe kumachitika chifukwa cha hemostatic agents omwe amagwiritsidwa ntchito panopa. Guluuyo amalowa pang'onopang'ono m'thupi mkati mwa miyezi ingapo. Ngati dokotalayo akufunika kukonza chilondacho atatha kugwiritsa ntchito koyamba, amathanso kuchotsedwa pasadakhale pogwiritsa ntchito njira yomwe imasungunuka.
Ofufuzawa tsopano akukonzekera kuyesa guluu pa zilonda zazikulu, ndipo akuyembekeza kuti izi zidzatsimikizira kuti guluuyo angagwiritsidwe ntchito pochiza zoopsa. Anaganizanso kuti zingakhale zothandiza panthawi ya opaleshoni, yomwe nthawi zambiri imafuna kuti dokotalayo azithera nthawi yambiri akuletsa kutuluka kwa magazi.
"Timatha kuchita maopaleshoni ambiri ovuta mwaukadaulo, koma kuthekera kwathu kuwongolera magazi kwambiri sikunakhale bwino," adatero Nabzdyk.
Njira ina yomwe ingagwiritsidwe ntchito ndikuthandizira kusiya kutuluka kwa magazi. Odwalawa ali ndi machubu apulasitiki omwe amalowetsedwa m'mitsempha yawo yamagazi, monga omwe amagwiritsidwa ntchito popangira ma catheter apakati kapena apakati kapena extracorporeal membrane oxygenation (ECMO). Pa nthawi ya ECMO, makina amagwiritsidwa ntchito kupopera magazi a wodwalayo kunja kwa thupi kuti awapatse okosijeni. Amagwiritsidwa ntchito pochiza anthu omwe ali ndi vuto lalikulu la mtima kapena mapapu. Chubuchi chimayikidwa kwa milungu ingapo kapena miyezi ingapo, ndipo kutuluka magazi pamalo oikapo kungayambitse matenda.
Zolemba: "Matani opangidwa ndi chingamu cha barnacle kuti asindikize mwachangu komanso mopanda kukhazikika kwa hemostatic" Olemba: Hyunwoo Yuk, Jingjing Wu, Tiffany L. Sarrafian, Xinyu Mao, Claudia E. Varela, Ellen T. Roche, Leigh G. Griffiths, Christoph S. . Nabzdyk ndi Xuanhe Zhao, 9 August 2021, Nature Biomedical Engineering.DOI: 10.1038/s41551-021-00769-y
Ofufuzawa adalandira ndalama kuchokera ku MIT Deshpande Center kuti awathandize kugulitsa guluu, zomwe akuyembekeza kuti akwaniritse pambuyo pa maphunziro owonjezera pazanyama. Kafukufukuyu adalandiranso ndalama kuchokera ku National Institutes of Health, National Science Foundation, ndi Office of Army Research kudzera ku Soldier Nanotechnology Institute ku Massachusetts Institute of Technology ndi Zoll Foundation.
Chonde, chonde gulitsani mwachangu. Mkazi wanga anatseka chilonda changa ndi guluu. Kuluma ngati gehena. Eya, mwina ndine khanda, monga amanenera nthaŵi zonse akafunsira.
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Nthawi yotumiza: Sep-09-2021